DNA Sequencing In Drug Discovery: Market outlook for applications, tools and services, and 40 company profiles

DNA Sequencing in Drug Discovery
Executive summary 14
Market overview 14
Market dynamics 15
Global DNA sequencing tools & services market 16
Company profiles 17
Chapter 1 Market overview 20
Summary 20
Evolution of DNA sequencing 21
DNA sequencing and drug discovery 22
Defining the market 24
Need for more reliable and compatible tools 24
High throughput and next-generation sequencing – attractive growth factors 25
DNA sequencing tools dominate the market 26
Protecting DNA sequencing technology 28
Applications of DNA sequencing 30
Drug development 31
Clinical trials 32
Whole genome testing 32
Toxicology prediction 32
Identification of drug resistance 32
Drug discovery 33
Chapter 2 Market dynamics 36
Summary 36
Introduction 37
Regional markets 37
North America 38
Europe 39
Asia 39
RoW 39
Competitive landscape 40
Recent agreements and collaborations 42
Recent launches 44
Market drivers 49
Funding from public institutes 49
NGS technologies 49
Patient profiling for genetic disorders 49
Development of personalized medicine 50
High productivity rates 50
Market restraints 50
Shift in sequencing market trends 50
Introduction of NGS technologies 50
Chapter 3 Global DNA sequencing tools & services market 54
Summary 54
DNA sequencing tools 55
Microarray 56
Biochip microarray 58
Gel array 58
Array design kit 59
Low and high density microarrays 60
Bioinformatics 60
Electrophoresis 62
Gel electrophoresis 63
Capillary electrophoresis 64
DNA sequencing kits 64
Consumables, chemicals, reagents and probes 65
DNA polymerase 66
Primers 67
Automated DNA sequencers 68
Chromatography 69
DNA amplification (PCR) 70
Mass spectrometry 71
Microscopy-based techniques 71
Electron microscopy 72
Atomic force microscopy 73
Microfluidics-enabled workstations 74
Barcode readers for DNA sample presentation 74
Computational chemistry and biology modeling 75
Spotters/arrayers 76
Centrifuge 77
Scanners 78
Thermal cyclers 78
Charge-coupled devices (CCDs) 79
Plates, strips and columns 80
DNA sequencing services 81
High throughput sequencing 82
Shotgun sequencing 83
Re-sequencing 83
Sample process and primer walking 84
Single pass analysis 85
Bacterial identification 86
Market drivers 87
Microarray technology is a powerful tool for high throughput screening 87
Increasing applications of microarrays 87
Increasing applications of bioinformatics in R&D 88
Technological breakthroughs generate need for efficient DNA sequencing 88
Genomics and drug discovery applications of automated sequencers 88
Diagnostic applications of automated sequencers 89
Applications in comparative research projects of automated sequencers 89
Developments in PCR technology 89
PCR is a reliable tool for multiple applications 89
Government initiative for funding 90
Market restraints 90
Limited scope of microarrays for pathogen enumeration 90
Time loss due to large number of laboratory specific variations for microarrays 90
Low cost next-generation technologies hinder growth of microarrays 90
Incompatibility issues of current bioinformatics tools 91
High cost of modifying supporting products 91
High cost and reliability issues of PCR technology 91
Chapter 4 Company profiles 94
Summary 94
454 Life Sciences 95
Company overview 95
Products and services 95
Company strategy 95
Other events 96
Affymetrix 97
Company overview 97
Product and services 98
Company strategy 98
Agilent Technologies 99
Company overview 99
Products and services 99
Company strategy 99
Beckman Coulter, Inc 100
Company overview 101
Products and services 101
Company strategy 101
Bio-Rad Laboratories 102
Company overview 102
Products and services 102
Company strategy 102
Caliper Life Sciences 103
Company overview 104
Products and services 104
Company strategy 104
CapitalBio Corp. 105
Company overview 105
Products and services 105
Company strategy 105
CombiMatrix Corp. 106
Company overview 107
Products and services 107
Company strategy 107
Commonwealth Biotechnologies, Inc 108
Company overview 108
Products and services 108
Company strategy 108
Complete Genomics, Inc 109
Company overview 109
Products and services 109
Company strategy 109
DNA Vision 110
Company overview 110
Products and services 111
Company strategy 111
Enzo Biochem, Inc 111
Company overview 111
Products and services 112
Company strategy 112
EPICENTRE Biotechnologies 112
Company overview 112
Products and services 113
Company strategy 113
Eurofins MWG Operon 113
Company overview 113
Products and services 114
Company strategy 114
GE Healthcare 115
Company overview 115
Products and services 115
Company strategy 116
Gen-Probe Life Sciences 116
Company overview 117
Products and services 117
Company strategy 117
GVK Biosciences (GVK BIO) 118
Company overview 118
Products and services 119
Company strategy 119
Helicos BioSciences Corp. 120
Company overview 120
Products and services 120
Company strategy 120
Illumina, Inc 121
Company overview 121
Products and services 122
Company strategy 122
Integrated DNA Technologies 123
Company overview 123
Products and services 123
Company strategy 123
Kapa Biosystems, Inc 124
Company overview 125
Products and services 125
Company strategy 125
Life Technologies Corp. 126
Company overview 126
Products and services 126
Company strategy 126
Microchip Biotechnologies, Inc 127
Company overview 127
Products and services 127
Company strategy 127
Nanogen, Inc 128
Company overview 128
Products and services 128
Company strategy 129
Ocimum Biosolutions Ltd. 130
Company overview 130
Products and services 130
Company strategy 130
Pacific Biosciences 131
Company overview 131
Company strategy 131
PamGene 132
Company overview 132
Products and services 132
Company strategy 133
Promega Corp. 133
Company overview 133
Products and services 134
Company strategy 134
QIAGEN 136
Company overview 136
Products and services 137
Company strategy 137
Sequenom 138
Company overview 138
Products and services 138
Company strategy 139
Shimadzu Biotech 140
Company overview 140
Products and services 141
Company strategy 141
Siemens Healthcare Diagnostics 141
Company overview 142
Products and services 142
Company strategy 142
Sigma-Aldrich 143
Company overview 143
Products and services 144
Company strategy 144
SoftGenetics, LLC. 144
Company overview 145
Products and services 145
Company strategy 145
Thermo Fisher Scientific, Inc 146
Company overview 146
Products and services 147
Company strategy 147
Third Wave Technologies, Inc 148
Company overview 148
Products and services 148
Company strategy 148
VisiGen Biotechnologies 149
Company overview 149
Products and services 150
Company strategy 150
ZS Genetics 150
Company overview 151
Products and services 151
Company strategy 151
Chapter 5 Appendix 153
Glossary 153
Patents 155
10
List of Figures
Figure 1.1: Developments in DNA sequencing 21
Figure 1.2: DNA sequencing in drug discovery and development 23
Figure 1.3: DNA sequencing and drug discovery market 24
Figure 1.4: Relative importance of features of DNA sequencing tools, 2009 versus 2014 25
Figure 1.5: DNA sequencing market drivers 26
Figure 1.6: DNA sequencing tools market dynamics 27
Figure 1.7: Patent analysis by technology, 2007 versus 2009 28
Figure 1.8: Patent analysis by geography, 2006 versus 2008 29
Figure 1.9: Patent applications (%) by competitors, 2004– Oct 09 30
Figure 2.10: Major segments of the global DNA sequencing market (%), 2008–09 41
Figure 2.11: Competitive landscape (%), 2008–09 42
List of Tables
Table 1.1: Global DNA sequencing market by tools and services ($m), 2007–14 26
Table 1.2: Global DNA sequencing applications market by applications ($m), 2007–14 31
Table 1.3: Global drug development market, by applications ($m), 2007–14 31
Table 1.4: Global drug discovery market, by applications ($m), 2007–14 33
Table 2.5: Global DNA sequencing market, by geography ($m), 2007–14 38
Table 2.6: Agreements and collaborations in the DNA sequencing market, 2008–09 43
Table 2.7: New product, technology & service launch in the DNA sequencing market, 2008–09 45
Table 2.8: New product, technology & service launch in the DNA sequencing market, 2008–09 (ctd1) 46
Table 2.9: New product, technology & service launch in the DNA sequencing market, 2008–09 (ctd2) 47
Table 2.10: New product, technology & service launch in the DNA sequencing market, 2008–09 (ctd3) 48
Table 3.11: Global DNA sequencing tools market, by geography ($m), 2007–14 55
Table 3.12: Global DNA sequencing tools market, by products ($m), 2007–14 56
Table 3.13: Global microarray market, by products ($m), 2007–14 57
Table 3.14: Global microarray market, by geography ($m), 2007–14 57
Table 3.15: Global biochip microarray market, by geography ($m), 2007–14 58
Table 3.16: Global gel array market, by geography ($m), 2007–14 59
Table 3.17: Global array design kit market, by geography ($m), 2007–14 59
Table 3.18: Global high and low density microarray market, by geography ($m), 2007–14 60
Table 3.19: Global bioinformatics market, by products ($m), 2007–14 61
Table 3.20: Global bioinformatics market, by geography ($m), 2007–14 62
Table 3.21: Global electrophoresis market, by products ($m), 2007–14 62
Table 3.22: Global electrophoresis market, by geography ($m), 2007–14 63
Table 3.23: Global gel electrophoresis market, by geography ($m), 2007–14 63
Table 3.24: Global capillary electrophoresis market, by geography ($m), 2007–14 64
Table 3.25: Global DNA sequencing kits and others market, by geography ($m), 2007–14 65
Table 3.26: Global consumables, chemicals, reagents and probes market, by products ($m), 2007–14 66
Table 3.27: Global consumables, chemicals, reagents and probes market, by geography ($m), 2007–14 66
Table 3.28: Global DNA polymerase market, by geography ($m), 2007–14 67
Table 3.29: Global primers market, by geography ($m), 2007–14 68
Table 3.30: Global automated DNA sequencers market, by geography ($m), 2007–14 69
Table 3.31: Global chromatography market, by geography ($m), 2007–14 69
Table 3.32: Global DNA amplification (PCR) market, by geography ($m), 2007–14 70
Table 3.33: Global mass spectrometry market, by geography ($m), 2007–14 71
Table 3.34: Global microscopy-based techniques market, by products ($m), 2007–14 72
Table 3.35: Global microscopy-based techniques market, by geography, ($m), 2007–14 72
Table 3.36: Global electron microscopy market, by geography ($m), 2007–14 73
Table 3.37: Global AFM market, by geography ($m), 2007–14 73
Table 3.38: Global microfluidics-enabled workstations market, by geography ($m), 2007–14 74
Table 3.39: Global barcode readers market for DNA sample presentation, by geography ($m), 2007–14 75
Table 3.40: Global computational chemistry and biology modeling market, by geography ($m), 2007–14 76
Table 3.41: Global spotters/arrayers market, by geography ($m), 2007–14 77
Table 3.42: Global centrifuge market, by geography ($m), 2007–14 77
Table 3.43: Global scanners market, by geography ($m), 2007–14 78
Table 3.44: Global thermal cycler market, by geography ($m), 2007–14 79
Table 3.45: Global charge-coupled devices market, by geography ($m), 2007–14 80
Table 3.46: Global plates, strips and columns market by geography ($m), 2007–14 80
Table 3.47: Global DNA sequencing services market by products ($m), 2007–14 81
Table 3.48: Global DNA sequencing services market, by geography ($m), 2007–14 82
Table 3.49: Global high throughput sequencing market, by geography ($m), 2007–14 82
Table 3.50: Global shotgun sequencing market, by geography ($m), 2007–14 83
Table 3.51: Global re-sequencing market, by geography ($m), 2007–14 84
Table 3.52: Global sample process and primer walking market by geography ($m), 2007–14 85
Table 3.53: Global single pass analysis market, by geography ($m), 2007–14 86
Table 3.54: Global bacterial identification market, by geography ($m), 2007–14 86
Table 5.55: US patents 155
Table 5.56: US patents (ctd 1) 156
Table 5.57: US patents (ctd 2) 157
Table 5.58: US patents (ctd 3) 158
Table 5.59: US patents (ctd 4) 159
Table 5.60: US patents (ctd 5) 160
Table 5.61: US patents (ctd 6) 161
Table 5.62: US patents (ctd 7) 162
Table 5.63: US patents (ctd 8) 163
Table 5.64: European patents 163
Table 5.65: European patents (ctd 1) 164
Table 5.66: European patents (ctd 2) 165
Table 5.67: European patents (ctd 3) 166
Table 5.68: European patents (ctd 4) 167
Table 5.69: European patents (ctd 5) 168
Table 5.70: European patents (ctd 6) 169
Table 5.71: European patents (ctd 7) 170
Table 5.72: European patents (ctd 7) 171
Table 5.73: European patents (ctd 8) 172
Table 5.74: European patents (ctd 9) 173
Table 5.75: European patents (ctd 10) 174
Table 5.76: European patents (ctd 11) 175
Table 5.77: Japanese patents 176
Table 5.78: Japanese patents (ctd 2) 177
Table 5.79: Japanese patents (ctd 3) 178
Table 5.80: Japanese patents (ctd 4) 179